GLP-1 receptor agonists—including Ozempic®, Mounjaro®, Semaglutide, and Tirzepatide—have been prescribed (on-and-off label) for weight management, including obesity, along with a reduced caloric diet and increased physical activity. Ozempic® and Mounjaro® are FDA-approved for type 2 diabetes treatment, but may be prescribed off-label for weight loss at a healthcare provider’s discretion. Take precaution with, and read all warnings concerning, GLP-1s, as they may cause serious side effects, including a risk of thyroid c-cell tumors. Do not use if you or your family have a history of a type of thyroid cancer called MTC (medullary thyroid carcinoma) or MEN 2 (multiple endocrine neoplasia syndrome). See important warnings & safety info about these medications. As an alternative to FDA-approved branded products, where appropriate, a provider may prescribe a GLP-1 compounded drug that is effective when prescribed off label for weight loss, which is prepared by a state-licensed sterile compounding pharmacy partner. Although GLP-1 compounded drugs are permitted to be prescribed under federal law, they are not FDA-approved and do not undergo safety, effectiveness, or manufacturing review. Thoroughly review all warnings and essential safety information regarding these drugs. See important safety information.
You’ll provide physical stats, medical history, and prescription preferences
If you meet qualifications, you’ll receive an Rx or schedule a virtual consultation
That’s it! Watch the weight fall off, and easily renew online when it’s time
GLP-1 Rx drug products require an assessment from a licensed healthcare provider who will determine if the medication is appropriate. Your clinician will make a treatment decision based on your medical history and overall health after the completion of a telehealth consultation. GLP-1 receptor agonists—including Ozempic®, Mounjaro®, Zepbound®, Wegovy®, Semaglutide, and Tirzepatide—have been prescribed (on-and-off label) for weight management, including obesity, along with a reduced caloric diet and increased physical activity. Ozempic® and Mounjaro® are FDA-approved for type 2 diabetes treatment, but may be prescribed off-label for weight loss at a healthcare provider’s discretion. Take precaution with, and read all warnings concerning, GLP-1s, as they may cause serious side effects, including a risk of thyroid c-cell tumors. Do not use if you or your family have a history of a type of thyroid cancer called MTC (medullary thyroid carcinoma) or MEN 2 (multiple endocrine neoplasia syndrome). See important warnings & safety info about these medications. As an alternative to FDA-approved branded products, where appropriate, a provider may prescribe a GLP-1 compounded drug that is effective when prescribed off label for weight loss, which is prepared by a state-licensed sterile compounding pharmacy partner. Although GLP-1 compounded drugs are permitted to be prescribed under federal law, they are not FDA-approved and do not undergo safety, effectiveness, or manufacturing review. Thoroughly review all warnings and essential safety information regarding these drugs.See important safety information.
Learn the science behind these similar but different GLP-1 medications to fully understand your options.
Check It Out >*Research suggests Mounjaro (tirzepatide) can lead to an average weight loss of 20–25% over a year when combined with a healthy lifestyle. Weight loss can vary depending on a patient’s response to the medication and ability to make lifestyle changes.
It’s vital to stay on top of your nutrient intake, digestive health, and gut microbiome while taking GLP-1s. This nutritionist-approved assortment is designed to support whole-body wellness along your weight-management journey.
Our team of advisors is here to empower patients to take control of their wellness journeys by combining medical, dietary, and healthy lifestyle expertise.
Whole Health Rx connects you with licensed medical providers for fast, affordable access to prescriptions, saving you from having to interrupt your day to visit a doctor’s office or urgent care.
At this time, the assessment questionnaire can only be completed by the person seeking care.
Asynchronous telehealth with Whole Health Rx allows you to receive care without live interaction with clinicians. First, you complete an Electronic Medical Record (EMR) provided intake questionnaire to fill out at your convenience. Then, the medical provider reviews your submissions and responds accordingly to enable flexible, timely treatment.
In some cases, an assigned provider may request a video conference. If so, you'll receive an email from OLA Digital Health to schedule your appointment. If requested, this appointment must be kept in order to ensure Rx approval.
Your privacy and the safety of your data are extremely important to us at Whole Health Rx. We adhere to strict privacy policies and employ advanced security measures to protect your information. Your Protected Health Information (PHI) is encrypted end-to-end and stored only by our Electronic Medical Record (EMR) provider. Whole Health Rx does not collect or store your PHI directly. We use industry standard TLS 1.2 encryption for all sensitive data in transit to be compliant with HIPAA regulations and SOC 2 certification standards, ensuring that your health information is handled with the utmost care and confidentiality. For further information, please review our Privacy Policy .
Customer support can be reached by emailing support@wholehealthrx.com.
While the Whole Health Rx services are available throughout most of the United States, certain states have laws that prevent clinicians from writing prescriptions without a live consultation and/or lab work. To see if Whole Health Rx is available to you, start an assessment questionnaire and enter your state. For further information, please review our Terms and Conditions.
Our GLP-1 prescription program is integrated with mail-order pharmacy fulfillment to ensure you receive your medication conveniently and on time. By streamlining the refill process, we also help support your medication adherence, ensuring you have what you need for your health journey.
For urgent or emergent issues, you should call 911 or go to the nearest emergency room or urgent care facility. The platform is not monitored immediately for urgent health submissions.
The Vitamin Shoppe’s Healthy Awards® loyalty program awards members points for every purchase from The Vitamin Shoppe, in-store or online, that can be redeemed for Cash Back Awards. Points are not earned on Whole Health Rx transactions, nor can Cash Back Awards be used for Whole Health Rx medication purchases. You CAN however earn points on—and redeem Cash Back Awards for—our GLP-1 Nutrient Support products, which are vital for your GLP-1 Rx journey.
Your subscription payment status and methods are managed by Stripe and can be managed directly on their website. You will receive several emails with additional details from Stripe immediately after your first payment and upon every renewal. These emails will Include links for you to access your Stripe payment portal.
You will be charged before your initial intake and upon every monthly renewal of your weight loss plan. If your renewal or initial intake is not approved by your doctor for any reason, the refund process will immediately start. The refund may take up to 7 days to process depending on your payment method.
We currently do not accept insurance for the medical weight loss program.
Once approved, to manage or cancel your subscription, click here. You’ll also be emailed a receipt from our partner, WellSync, immediately upon successful payment, before completing the assessment questionnaire. At the bottom, you’ll find a link to "Manage/Cancel Your Subscription." By clicking this button, you’ll be brought to our billing provider, Stripe, where you’ll enter the email address used for payment. You’ll then be sent a link to access your portal. There, you’ll find a button on the main screen to cancel the subscription. This will cancel it immediately, and you won’t be charged for the upcoming scheduled payment.
We'll ensure your refills occur monthly until you cancel. You’ll be charged roughly one month after you initially submitted your initial assessment questionnaire. You will also receive a mandatory renewal questionnaire on that date. Refill medication will not be shipped until the renewal questionnaire has been completed—even if you’ve made a payment—as the assigned medical provider must review the assessment before prescribing the next month of medication.
Your medical provider will submit your prescription directly to the pharmacy electronically. The pharmacy then takes over to fill your prescription in preparation for shipping to your provided shipping address.
After your prescription is filled, the pharmacy will ship your medication directly to you at the address you provided during the checkout process.
After reviewing your assessment questionnaire, your medical provider may reach out for additional information using the phone number or email you provided.
Medical weight loss GLP-1 prescriptions are written by licensed and experienced medical providers, including physicians, nurse practitioners, and specialists, ensuring safe and personalized medication management.
To change medications, simply cancel your current subscription and start the assessment questionnaire, indicating your desired medication.
Whole Health Rx makes it simple to start your GLP-1 journey. Start by taking a brief questionnaire about your health history. Here, you can select your preferred type of medication from the available options. Then, an experienced healthcare practitioner will review your submission and, if you qualify, they will write a prescription. This process makes getting a tirzepatide or semaglutide prescription online quick and easy.
As soon as you visit our medical weight loss landing page, you will be guided to complete a secure payment process via Stripe. After this, you will gain access to our medical weight loss intake form. In this form, you will share your medical history, upload photos related to your health concerns, describe your weight loss goals, and provide a government-issued ID. This detailed information allows the provider to make a legal and informed medical decision. A medical provider will then carefully review your submitted information to determine if the treatment you are seeking is right for you. Within a few hours of your submission, you should expect a follow-up from your assigned provider via the contact information you provided during your intake to discuss the next steps. In some cases, a live video consultation may be required before prescription approval.
This decision is made based on clinical guidelines and your health assessment by our licensed medical professionals. However, disqualification in the intake process usually occurs due to certain health-related criteria, such as Body Mass Index (BMI) and the presence of certain comorbidities. In rare cases, unwillingness to commit to reducing caloric intake or to engage in physical activity may also lead to disqualification. These measures are in place to ensure that our services are suitable and safe for your health needs.
Sometimes, it could be a glitch or a file size issue. Here are a few things you can try:
If you do not qualify for a medical weight loss GLP-1 treatment, your payment will be immediately refunded. If this does not occur, please contact our support team at support@wholehealthrx.com.
GLP-1 medications are a class of drugs specifically aimed at aiding weight management and are used in the treatment of obesity and type-2 diabetes. They are named after the natural hormone they mimic, Glucagon-like Peptide-1 (GLP-1), which your body produces and is secreted by intestinal enteroendocrine L-cells and certain neurons in the brainstem upon food intake.
GLP-1 medications work by mimicking the natural GLP-1 hormone, which is released by your intestines after you eat. This hormone plays a critical role in signaling to your brain that you are full, helping to control your appetite. By leveraging this mechanism, GLP-1 medications make you feel fuller sooner and longer after eating, which can lead to reduced calorie intake and subsequent weight loss. GLP-1s are also valuable for improving blood sugar levels, offering a dual benefit for individuals with obesity and type 2 diabetes.
The popularity of GLP-1 medications is on the rise due to their proven effectiveness in not only helping individuals lose weight but also in managing blood sugar levels, which is particularly beneficial for those with type 2 diabetes. The demand for innovative obesity treatments is growing, and GLP-1 medications offer a promising solution.
When using GLP-1 medications, you might experience several benefits including a notable reduction in body weight, decreased appetite, improved blood sugar levels, and even some cardiovascular advantages such as a reduced risk of heart attack and stroke in certain individuals.
Yes, while GLP-1 medications can be highly beneficial, they may come with potential side effects. Common side effects include gastrointestinal issues such as nausea and vomiting, a possible increased risk of pancreatitis, low blood sugar levels especially when combined with other medications, and reactions at the injection site. It is also important to note that these medications are not recommended for individuals with certain medical histories related to thyroid cancer. See important safety information here.
Deciding if GLP-1 medications are suitable for you involves an evaluation with a medical provider. They will consider your individual health status, weight loss goals, and any potential risks to determine if this treatment aligns with your needs and health.
When using GLP-1s, you may not feel as hungry and therefore may eat less, so it’s important to ensure your nutritional needs are still being met. Find supplements including protein, multivitamins, fiber, and probiotics to fill in any nutritional gaps and support gut health throughout your weight-loss journey.
While GLP-1 drugs were initially used for diabetes, they are now an increasingly popular category of medication used for weight loss. The GLP-1 medications available here, if prescribed, include:
Compound Semaglutide (Injection)
Compound Tirzepatide (Injection)
Compound Semaglutide (Orally Dissolving Tablets)
Compound Tirzepatide (Orally Dissolving Tablets)
Ozempic® (Semaglutide Injection)Mounjaro® (Tirzepatide Injection)
Zepbound® (Tirzepatide Injection)
Wegovy® (Semaglutide Injection)
Compounded medications are patient-specific medications created in a state Board of Pharmacy or FDA licensed compounding facility per a prescription from a licensed healthcare professional. Compounded drugs are required to exclusively use ingredients from FDA-licensed facilities, and test sterile compounds for potency, sterility, and purity. While compounded drugs are legal they do not undergo pre-market approval from the FDA as they are not made in large batches for the public, compounds are made based on specific orders from a medical professional. Because of that the dose, route of administration, and efficacy may differ from commercially available, brand-name, drugs.
Semaglutide contributes to weight loss primarily by mimicking the action of the incretin hormone GLP-1, which regulates appetite and calorie intake. It slows gastric emptying, enhances satiety, and reduces hunger, leading to a lower caloric intake. Additionally, it improves glycemic control by stimulating insulin secretion and inhibiting glucagon release. Its effectiveness in significant and sustained weight loss, coupled with its ability to improve various cardiovascular and metabolic parameters, makes it a highly effective option for the treatment of obesity and type 2 diabetes. In addition, it is particularly effective for individuals without diabetes, with some experiencing over 20% weight loss within 6 months.
When using semaglutide for weight loss, safety considerations and potential side effects are crucial to understand. Common side effects include gastrointestinal issues such as nausea, diarrhea, constipation, and abdominal pain. There is also a risk of more serious side effects, including pancreatitis, gallbladder problems, and changes in vision. Additionally, significant appetite reduction could result in nutritional deficiencies if not managed with a balanced diet. It is essential to discuss these potential risks and side effects with your healthcare provider to ensure it aligns with your health goals and conditions.
Semaglutide supports long-term weight management and overall health through multiple mechanisms, primarily by acting on the GLP-1 receptors to regulate appetite and improve insulin sensitivity. This action not only aids in reducing caloric intake by enhancing feelings of satiety and reducing hunger but also helps in slowing down gastric emptying, which contributes to prolonged feelings of fullness. Additionally, semaglutide has been shown to have a positive impact on metabolic health, including improving blood glucose levels and potentially reducing the risk of cardiovascular diseases by improving parameters such as blood pressure and lipid profiles. The sustained weight loss achieved with semaglutide, as evidenced in clinical trials, suggests minimal weight regain over time when therapy is continued, highlighting its role in long-term weight management. Moreover, the reduction in appetite and changes in food preferences towards lower-fat options contribute to a healthier diet, further supporting overall health.
Eligibility for semaglutide treatment for weight loss primarily targets adults with obesity or overweight conditions who have not achieved significant weight loss through diet and exercise alone. Specifically, individuals with a body mass index (BMI) of 30 or higher (obese), or a BMI of greater than 27 and less than 30 (overweight) with at least one weight-related health condition such as type 2 diabetes, high blood pressure, or high cholesterol, may qualify for semaglutide treatment. Before prescribing semaglutide for weight loss, doctors conduct a thorough medical evaluation to assess your overall health, review your medical history, current medications, and any potential risks or contraindications for semaglutide treatment. This evaluation is crucial to ensure your safety and appropriateness of semaglutide.
Maintaining a healthy lifestyle while using semaglutide for weight loss is essential and is strongly recommended to complement the medication's effects. Semaglutide, a GLP-1 receptor agonist, contributes to weight loss by reducing appetite and caloric intake, but it should not replace exercise and dietary changes. Instead, it is an adjunct treatment designed to enhance the benefits of a healthy diet and regular physical activity. Lifestyle changes such as adopting a healthier diet, increasing physical activity, and making behavioral changes are crucial for achieving long-term weight reduction and health benefits.
Tirzepatide has shown promising results in enhancing weight loss with sustained treatment. For example, in the SURMOUNT-4 trial, participants who continued tirzepatide treatment experienced further weight reduction, while those who switched to a placebo saw weight regain. However, even with the regain, they remained significantly below their initial weight, indicating that tirzepatide can have lasting benefits even after discontinuation. The study highlights the necessity of ongoing pharmacological intervention for chronic weight management, akin to treatments for other chronic conditions such as diabetes and hypertension. Despite these benefits, challenges include managing side effects and ensuring your adherence to long-term therapy.
Common side effects of tirzepatide include gastrointestinal issues such as nausea, vomiting, diarrhea, and stomach pain. Less common but more severe side effects might include difficulty breathing, skin reactions, and signs of liver problems such as yellow eyes or skin. While many side effects may not require medical attention and could diminish over time, managing more severe reactions might necessitate consulting healthcare professionals promptly. Strategies to mitigate these side effects include starting with a lower dose and gradually increasing it to improve tolerance.
Tirzepatide's effectiveness in controlling blood sugar and promoting weight loss is attributed to its dual action as a GLP-1 and GIP receptor agonist. This dual mechanism enhances insulin secretion and reduces hyperglycemia more effectively than treatments targeting only the GLP-1 receptor, contributing to significant weight loss and improved metabolic health. Tirzepatide also reduces appetite and delays gastric emptying, which helps in reducing caloric intake and promoting weight loss.
Yes, tirzepatide has been shown to significantly reduce appetite and energy intake, contributing to weight loss in individuals with type 2 diabetes. In a study comparing tirzepatide with Semaglutide and a placebo, tirzepatide led to notable reductions in body weight and fat mass, primarily through decreased energy intake at meals. While both tirzepatide and semaglutide reduced appetite, tirzepatide's superior weight loss outcomes suggest that other mechanisms, including increased energy expenditure, also play a role.
Those considering tirzepatide for weight loss should be aware of its administration as a once- weekly subcutaneous injection, which may be accompanied by common side effects such as nausea, diarrhea, and injection site reactions. The medication's dosage should be gradually increased to minimize side effects. Tirzepatide has been approved for chronic weight management in adults with obesity or overweight conditions in conjunction with a reduced- calorie diet and increased physical activity.
Tirzepatide possesses a unique ability to stimulate insulin secretion by targeting two different mechanisms in the body: the GLP-1 and GIP receptors. This dual action enhances the drug's effectiveness in lowering blood glucose levels in those with type 2 diabetes. Tirzepatide's capacity to activate these receptors not only restores insulin production but also helps in reducing appetite, which contributes to weight loss over time. This dual receptor activation offers a broader range of activity within the body, distinguishing tirzepatide from other diabetes therapies.
GIP (Glucose-dependent Insulinotropic Polypeptide) and GLP-1 (Glucagon-Like Peptide-1) are both important hormones released after eating to help regulate your insulin levels, but they have some key differences. GIP is primarily found in the upper part of your small intestine and is known for its role in managing insulin in response to meals, particularly those rich in glucose and fats. On the other hand, GLP-1, which comes from a different part of the gut, not only helps with insulin but also has a broader range of benefits, including reducing appetite, slowing down how quickly your stomach empties after eating, and even having protective effects on the brain. While GLP-1 has been used successfully in treating diabetes and aiding in weight loss, GIP's potential is still being explored, particularly when used together with GLP-1. This distinction makes GLP-1 a particularly valuable tool in managing blood sugar levels and weight, offering more than just insulin regulation.
Tirzepatide is unique because it works on two fronts by targeting both GLP-1 and GIP receptors in your body. This dual action helps to control blood sugar levels and supports weight loss more effectively than medications that focus on just one receptor. By influencing both pathways involved in metabolic regulation, tirzepatide offers a broader approach to managing type 2 diabetes and obesity, potentially leading to better health outcomes. This dual approach is a key factor in why tirzepatide might be a particularly effective treatment option for some individuals.
Prescription products require an online medical assessment and consultation with a healthcare provider who will determine if a prescription is appropriate. The Vitamin Shoppe will match you with an independent licensed physician who will evaluate whether or not you are an appropriate candidate for any prescription products. If appropriate, the physician may write you a prescription for the product that can be picked up at your local pharmacy.
The information provided on this page is for informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. If you have any questions or concerns about your health, please talk to a doctor. The Vitamin Shoppe is not offering advice, recommending or endorsing any specific prescription drug, pharmacy, or other information on the site. The Vitamin Shoppe provides no warranty for any information. Please seek medical advice before starting, changing, or terminating any medical treatment. The independent licensed healthcare provider through our virtual healthcare platform can conduct an initial evaluation of your symptoms but may need to refer you to a specialist or for in-person treatment. If you are experiencing life-threatening symptoms, seek emergency medical attention immediately.
The Vitamin Shoppe is not sponsored by or affiliated with any of the third-party brands identified. Trademarks, brands, logos, and copyrights are the property of their respective owners. Ozempic® is registered trademarks of Novo Nordisk A/S. Mounjaro® and its delivery device base are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.
Compounded medications are made in State Board of Pharmacy-licensed sterile compounding pharmacies, or FDA-licensed 503(b) Outsourcing Facilities. While these facilities are strictly regulated, the compounded medications they make are not FDA-approved, as they are compounded based on an individual provider’s prescription for a specified patient. Strength, dose, route of administration, and other variables may make compounded medications different from FDA-approved drugs which makes directly comparing results & risk profiles between FDA-approved drugs and compounded drugs difficult. Any compounded drugs prescribed are based on a licensed provider’s medical judgment based on a telehealth encounter and medical history.
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