Whole Health Rx^™ by The Vitamin Shoppe^® is your guide along the path of lifelong wellness, with convenient virtual care from experienced providers. Whole Health Rx provides easily accessible educational resources to illuminate all clinical and nutritional options and inform decision-making, empowering you to take control of your health and wellness journey. 

At this time, the assessment questionnaire can only be completed by the person seeking care.

Yes, a virtual consultation with your provider is required to go over the results of your labs and must be completed in order to ensure Rx approval.

Your privacy and the safety of your data are extremely important to us at Whole Health Rx. We adhere to strict privacy policies and employ advanced security measures to protect your information. Your Protected Health Information (PHI) is encrypted end-to-end and stored only by our Electronic Medical Record (EMR) provider. Whole Health Rx does not collect or store your PHI directly. We use industry standard TLS 1.2 encryption for all sensitive data in transit to be compliant with HIPAA regulations and SOC 2 certification standards, ensuring that your health information is handled with the utmost care and confidentiality. For further information, please review our Privacy Policy.

Customer support can be reached at (866) 409-8371, or by emailing support@wholehealthrx.com.

The Vitamin Shoppe’s free Healthy Awards^® loyalty program awards its members points for every purchase from The Vitamin Shoppe, in-store or online, that can be redeemed for Cash Back Awards. Points are not earned on Whole Health Rx transactions, nor can Cash Back Awards be used for Whole Health Rx medication purchases. You CAN however earn points on—and redeem Cash Back Awards for—products that work alongside your TRT treatment, like protein powder, creatine, prostate support, and multivitamins, which are vital for your wellness journey.

Your treatment plan payment status and methods are managed by Recurly and can be accessed directly on their website. You’ll receive several emails with additional details, including how to activate your Recurly account for easy updates immediately after your first payment. You can login to your account with Recurly at https://wellsync.recurly.com and all invoices will include links to this portal as well.

You will be charged at the end of your initial assessment and upon every 3-month renewal of your TRT plan. If your renewal or initial intake is not approved by your doctor for any reason, the refund process will immediately start. The refund may take up to 7 days to process depending on your payment method.

We currently do not accept insurance for our TRT program.

To manage or cancel your treatment plan, please contact our support team at support@wholehealthrx.com.

KYZATREX is an FDA-approved, twice-daily oral capsule for testosterone replacement therapy in adult males with conditions associated with deficiency or absence of endogenous testosterone, also known as hypogonadism. It helps increase testosterone levels, addressing issues like reduced libido, fatigue, and muscle loss. Studies show small increases in systolic blood pressure, especially in those on antihypertensive therapy, with minimal changes in diastolic blood pressure and heart rate. Careful monitoring is recommended for patients with hypertension. Overall, KYZATREX is effective for testosterone replacement with manageable impacts on blood pressure ^[1][2]. See Important Safety Information here.

References: 
‍^[1] White, W. B., Bernstein, J. S., Rittmaster, R., & Dhingra, O. (2021). Effects of the oral testosterone undecanoate KYZATREXTM on ambulatory blood pressure in hypogonadal men. The Journal of Clinical Hypertension, 23(7), 1420–1430. https://doi.org/10.1111/jch.14297  
‍^[2] Why KYZATREX | Safe to Use, Easy to Take, and Up to 96% Effective. (n.d.). KYZATREX. Retrieved May 17, 2024, from https://www.KYZATREX.com/why-KYZATREX/ 

KYZATREX is an oral testosterone replacement therapy. It is absorbed through the lymphatic system, avoiding the liver's initial breakdown, which helps maintain stable testosterone levels. Once in the body, KYZATREX converts to active testosterone, which binds to receptors in muscles, bones, and other tissues, improving energy, sex drive, and muscle mass. Testosterone works by binding to androgen receptors, which then regulate genes involved in male health and development. This process supports muscle growth, bone density, and sexual function, making KYZATREX effective in treating low testosterone levels^{[1][2][3][4][5][6]}. See Important Safety Information here.

References:
^[1] Kim, Y., Lee, D., Jo, H., Go, C., Yang, J., Kang, D., & Kang, J. S. (2021). GV1001 interacts with androgen receptor to inhibit prostate cell proliferation in benign prostatic hyperplasia by regulating expression of molecules related to epithelial-mesenchymal transition. Aging, 13(3), 3202–3217. https://doi.org/10.18632/aging.202242  
‍^[2] Ayoub, R., Page, S. T., Swerdloff, R. S., Liu, P. Y., Amory, J. K., Leung, A., Hull, L., Blithe, D., Christy, A., Chao, J. H., Bremner, W. J., & Wang, C. (2016). Comparison of the single dose pharmacokinetics, pharmacodynamics, and safety of two novel oral formulations of dimethandrolone undecanoate (DMAU): a potential oral, male contraceptive. Andrology, 5(2), 278–285. https://doi.org/10.1111/andr.12303  
‍^[3] Thomas, P. (2019). Membrane Androgen Receptors Unrelated to Nuclear Steroid Receptors. Endocrinology, 160(4), 772–781. https://doi.org/10.1210/en.2018-00987  
‍^[4] White, W. B., Bernstein, J. S., Rittmaster, R., & Dhingra, O. (2021). Effects of the oral testosterone undecanoate KYZATREXTM on ambulatory blood pressure in hypogonadal men. The Journal of Clinical Hypertension, 23(7), 1420–1430. https://doi.org/10.1111/jch.14297  
‍^[5] A. Michael Lincoff, Bhasin, S., Panagiotis Flevaris, Mitchell, L. M., Shehzad Basaria, Boden, W. E., Cunningham, G. R., Granger, C. B., Khera, M., Thompson, I. M., Wang, Q., Wolski, K., Davey, D., Vidyasagar Kalahasti, Khan, N., Miller, M. G., Snabes, M. C., Chan, A., Dubcenco, E., & Li, X. (2023). Cardiovascular Safety of Testosterone-Replacement Therapy. https://doi.org/10.1056/nejmoa2215025
 ^[6] Why KYZATREX | Safe to Use, Easy to Take, and Up to 96% Effective. (n.d.). KYZATREX. Retrieved May 17, 2024, from https://www.KYZATREX.com/why-KYZATREX/

An undecanoate is a type of chemical compound used to make testosterone last longer in the body. Specifically, testosterone undecanoate is testosterone attached to an undecanoate ester, which slows down its release into the bloodstream. This means it provides a steady and prolonged effect, making it useful for testosterone replacement therapy. The undecanoate helps testosterone be absorbed through the lymphatic system when taken orally, avoiding rapid breakdown in the liver and maintaining stable testosterone levels^[1][2][3]. 
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References: 
‍^[1] Edelstein, D., & Basaria, S. (2010). Testosterone undecanoate in the treatment of male hypogonadism. Expert Opinion on Pharmacotherapy, 11(12), 2095–2106. https://doi.org/10.1517/14656566.2010.505920  
‍^[2] Testosterone undecanoate--oral therapy for male hypogonadism. (1985). Drug and therapeutics bulletin, 23(2), 7–8. 
‍^[3] Kapoor, A. (2016). What’s new in testosterone deficiency research? Canadian Urological Association Journal, 10(5-6S), 130. https://doi.org/10.5489/cuaj.3915  

Our TRT service is currently available in 44 states (for now), excluding New York, New Jersey, Rhode Island, Connecticut, South Carolina, and Alabama.

KYZATREX is intended for men who have low testosterone due to certain medical conditions. Your healthcare provider can determine if KYZATREX is suitable for you based on your medical history and current health.
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It is not known if KYZATREX is safe or effective in males younger than 18 years old. Improper use may affect bone growth in children.
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Do not take KYZATREX if you: have breast cancer; have or might have prostate cancer; are a woman who is pregnant (KYZATREX may harm your unborn baby); are allergic to KYZATREX or any of its ingredients; or have low testosterone without certain medical conditions (e.g., do not take KYZATREX if you have low testosterone due to age). Start the conversation with your doctor.

We understand that women can experience an imbalance in hormones including testosterone, but currently, KYZATREX is only to be used by men. Due to lack of controlled studies, and potential virilizing effects, KYZATREX is not indicated for use in women. Females experiencing issues with their hormone levels should seek guidance from their medical providers regarding TRT for women and other alternative treatment options.

Testosterone Replacement Therapy (TRT) is a treatment for men with low testosterone levels, a condition known as hypogonadism. Symptoms of hypogonadism can include decreased libido, fatigue, and loss of muscle mass. To qualify for TRT, you need to have low serum testosterone levels (below 300 to 350 ng/dL) on two separate morning tests and show symptoms of hypogonadism. TRT comes in different forms, such as topical gels and intramuscular injections, and the choice depends on factors like cost and your preference. 
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While TRT can effectively improve symptoms and enhance quality of life, it requires careful selection, shared decision-making with your doctor, and close monitoring due to potential risks. Studies have shown that TRT can help improve symptoms and quality of life in men with low testosterone levels, but there are concerns about possible cardiovascular risks and long-term safety. Guidelines for TRT emphasize the need for personalized treatment plans and following clinical recommendations to avoid misuse. Despite some controversies, TRT is a commonly used treatment for hypogonadism, with ongoing research to better understand its benefits and risks^[1][2][3]. 

References: 
‍^[1] Snow, L. (2023). Hormone Therapy: Testosterone Replacement Therapy. FP Essentials, 531, 7–14. https://pubmed.ncbi.nlm.nih.gov/37603880/  
^[2] Park, H., Ahn, S., & Moon, D. (2019). Evolution of Guidelines for Testosterone Replacement Therapy. Journal of Clinical Medicine, 8(3), 410. https://doi.org/10.3390/jcm8030410
 ^[3] Skiba, R., Rymarz, A., Matyjek, A., Dymus, J., Woźniak-Kosek, A., Syryło, T., Zieliński, H., & Niemczyk, S. (2022). Testosterone Replacement Therapy in Chronic Kidney Disease Patients. Nutrients, 14(16), 3444. https://doi.org/10.3390/nu14163444

Diagnosing Low T involves simple lab tests to measure your Total Testosterone (Total T) and Free Testosterone (Free T), along with Sex Hormone Binding Globulin (SHBG), which affects Free T availability. Total T gives an overall level, while Free T shows the testosterone available for your body’s use. High SHBG can lower Free T, impacting its availability. Your doctor may suggest these tests and follow-up labs to monitor your testosterone levels over time, ensuring your treatment is accurately tailored to your needs.

KYZATREX testosterone therapy is administered orally, with two doses a day alongside food in pill form. This method is designed to be convenient and maintain stable testosterone levels in the body. Oral testosterone undecanoate is effective for increasing testosterone levels in individuals with hypogonadism. Compared to traditional methods like injections, patches, or gels, the oral form is less invasive and can improve compliance and comfort ^[1]. See Important Safety Information here.
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References: 
^[1] Miller, J., Nguyen, T., Loeb, C., Khera, M., & Yafi, F. A. (2023). Oral testosterone therapy: past, present, and future. Sexual Medicine Reviews, 11(2), 124–138. https://doi.org/10.1093/sxmrev/qead003  

KYZATREX testosterone therapy can offer several benefits for individuals with testosterone deficiency. It can improve sexual function by enhancing libido and erectile function, and it can boost mood and emotional well-being by alleviating symptoms of depression, irritability, and fatigue. Benefits of TRT for men can also include an increase muscle mass and strength, improved bone density, and help with the prevention of osteoporosis. For individuals with type 2 diabetes, TRT can improve glycemic control and insulin sensitivity. Additionally, TRT may positively impact cardiovascular health, cognitive functions like memory and processing speed, and overall quality of life. However, TRT should be administered under medical supervision, with regular monitoring to ensure safety and manage potential risks such as increased red blood cell count and cardiovascular concerns^{[1][2][3][4][5]}. See Important Safety Information here.
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References: 
^[1] Renke, G., & Tostes, F. (2023). Cardiovascular Safety and Benefits of Testosterone Implant Therapy in Postmenopausal Women: Where Are We? Pharmaceuticals, 16(4), 619. https://doi.org/10.3390/ph16040619  
‍^[2] Lawton, J., & Amjad, M. (2023). Weighing the Benefits and Drawbacks of Testosterone Replacement Therapy. Sciential - McMaster Undergraduate Science Journal, 10. https://doi.org/10.15173/sciential.v1i10.3364  
‍^[3] Yeo, S., Holl, K., Peñaherrera, N., Wissinger, U., Anstee, K., & Wyn, R. (2021). Burden of Male Hypogonadism and Major Comorbidities, and the Clinical, Economic, and Humanistic Benefits of Testosterone Therapy: A Narrative Review. ClinicoEconomics and Outcomes Research, Volume 13, 31–38. https://doi.org/10.2147/ceor.s285434
 ^[4] Kumari, K., Kumar, R., Memon, A., Kumari, B., Tehrim, M., Kumari, P., Shehryar, M., Islam, H., Islam, R., Khatri, M., Kumar, S., & Kumar, A. (2023). Treatment with Testosterone Therapy in Type 2 Diabetic Hypogonadal Adult Males: A Systematic Review and Meta-Analysis. Clinics and Practice, 13(2), 454–469. https://doi.org/10.3390/clinpract13020041  
‍^[5] Fatih Aktoz, Ali Can Gunes, & Cemal Tamer Erel. (2023). What is the Role of Testosterone Therapy in Postmenopausal Women? A SWOT Analysis. Clinical and Experimental Obstetrics & Gynecology, 50(8), 159–159. https://doi.org/10.31083/j.ceog5008159

KYZATREX testosterone therapy can be used to treat erectile dysfunction (ED), particularly in men with low testosterone levels (hypogonadism). Studies show that testosterone therapy can significantly improve ED symptoms in hypogonadal men, with 91.9% of young men with organic ED reporting improvement after therapy^[1]. Combining testosterone therapy with PDE5 inhibitors, like sildenafil, has proven effective for men who do not respond to PDE5 inhibitors alone, restoring erectile function in 70% of diabetic participants^[2]. Long-term testosterone therapy has shown benefits in improving erectile function in men with functional hypogonadism and obesity, with significant improvements noted over up to 13 years^[5]. Testosterone therapy has also been effective in men with venous leakage, with some reporting significant improvement within 12-20 weeks of treatment^[3]. Additionally, in men with type 2 diabetes and hypogonadism, long-acting testosterone undecanoate improved sexual function and quality of life, including better IIEF scores^[4]. Regular monitoring and a tailored approach by healthcare providers are essential to maximize benefits and manage potential risks.See Important Safety Information here.

References: 
^[1] Song, J., G Saffati, Naeem, T., Biles, B., Pierce, H., Lipshultz, L., & Khera, M. (2024). (160) Improving Symptoms in Young Men with Erectile Dysfunction: Testosterone Therapy with or Without PDE5 Inhibitors. ˜the œJournal of Sexual Medicine, 21(Supplement_1). https://doi.org/10.1093/jsxmed/qdae001.151  
‍^[2] Kalinchenko, S. Y., Kozlov, G. I., Gontcharov, N. P., & Katsiya, G. V. (2003). Oral testosterone undecanoate reverses erectile dysfunction associated with diabetes mellitus in patients failing on sildenafil citrate therapy alone. The Aging Male: The Official Journal of the International Society for the Study of the Aging Male, 6(2), 94–99. https://pubmed.ncbi.nlm.nih.gov/12898793/  
‍^[3] Yassin, A., Saad, F., & Traish, A. M. (2006). Testosterone Undecanoate Restores Erectile Function in a Subset of Patients with Venous Leakage: A Series of Case Reports. The Journal of Sexual Medicine, 3(4), 727–735. https://doi.org/10.1111/j.1743-6109.2006.00267.x  
‍^[4] Hackett, G., Cole, N., Bhartia, M., Kennedy, D., Raju, J., & Wilkinson, P. (2013). Testosterone Replacement Therapy with Long‒Acting Testosterone Undecanoate Improves Sexual Function and Quality‒of‒Life Parameters vs. Placebo in a Population of Men with Type 2 Diabetes. The Journal of Sexual Medicine, 10(6), 1612–1627. https://doi.org/10.1111/jsm.12146  
‍^[5] Saad, F., Haider, K. S., Haider, A., Doros, G., & A Traish. (2023). (396) Effects of Long-term Testosterone Therapy in Men with Functional Hypogonadism and Obesity on Weight, Waist Circumference, and Erectile Function – Results from a Registry Study. ˜the œJournal of Sexual Medicine, 20(Supplement_1). https://doi.org/10.1093/jsxmed/qdad060.370  

KYZATREX may cause a small increase in 24-hour ambulatory systolic blood pressure, especially in those on antihypertensive therapy. Diastolic blood pressure and heart rate changes are minimal. Other potential side effects include headaches, mood changes, and increased red blood cell count. Monitoring is recommended for patients with hypertension or those on antihypertensive drugs to manage potential risks^[1][2].
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KYZATREX may cause other serious side effects including:

• Increase in red blood cell count (hematocrit) or hemoglobin, which can increase the risk of blood clots, strokes, and heart attacks. You may need to stop KYZATREX if your red blood cell count increases.
• If you already have an enlarged prostate, your signs and symptoms may worsen while taking KYZATREX. These may include: increased urination at night, trouble starting your urine stream, urinating many times during the day, urge to go to the bathroom right away, a urine accident, inability to pass urine or weak urine flow.
• Increased risk of prostate cancer
• Blood clots in the legs or lungs: Signs and symptoms of a blood clot in your leg can include pain, swelling or redness. Signs and symptoms of a blood clot in your lungs can include difficulty breathing or chest pain.
• Abuse: Testosterone can be abused when taken at higher than prescribed doses and when used with other anabolic androgenic steroids. Abuse can cause serious heart and psychological side effects.
• In large doses, KYZATREX may lower your sperm count
• Liver problems: Symptoms of liver problems may include: nausea or vomiting; yellowing of your skin or whites of your eyes; dark urine; pain on the right side of your stomach area (abdominal pain).
• Swelling of your ankles, feet, or body (edema), with or without heart failure
• Enlarged or painful breasts
• Breathing problems while you sleep: TRT in men with hypogonadism may have increased potential of experiencing sleep apnea. 

Call your healthcare provider right away if you have any of the serious side effects listed above.
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The most common side effect of KYZATREX is high blood pressure.  Other side effects may include: headache, joint or back pain, diarrhea, increased red blood cell count, anxiety, constipation, swelling of the legs, and increased prostate specific antigen (PSA) levels.
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These are not all the possible side effects of KYZATREX. For more information, ask your healthcare provider or pharmacist.
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088. You may also report side effects to Marius by visiting www.mariuspharma.com.
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See Full Prescribing Information and Medication Guide for KYZATREX.
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Keep KYZATREX and all medicines out of the reach of children.
^[1] White, W. B., Bernstein, J. S., Rittmaster, R., & Dhingra, O. (2021). Effects of the oral testosterone undecanoate KYZATREX on ambulatory blood pressure in hypogonadal men. The Journal of Clinical Hypertension, 23(7), 1420–1430. https://doi.org/10.1111/jch.14297  
‍^[2] Österbrand, M., Fors, H., & Ensio Norjavaara. (2023). Pharmacological treatment for pubertal progression in boys with delayed or slow progression of puberty: A small-scale randomized study with testosterone enanthate and testosterone undecanoate treatment. Frontiers in Endocrinology, 14. https://doi.org/10.3389/fendo.2023.1158219  

KYZATREX appears to be a safe and effective option for testosterone replacement therapy in older men. Studies show that it has a stable cardiovascular profile with minimal increases in blood pressure and heart rate. It effectively increases testosterone levels and improves well-being without significant adverse effects^[2]. However, it's important for older men to monitor their cardiovascular and prostate health regularly while on TRT. Consulting with a healthcare provider to discuss individual risks and benefits is crucial^[1][3][4]. See Important Safety Information here.
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References: 
^[1] Chrysant, S. G., & Chrysant, G. S. (2018). Cardiovascular benefits and risks of testosterone replacement therapy in older men with low testosterone. Hospital Practice, 46(2), 47–55. https://doi.org/10.1080/21548331.2018.1445405  
‍^[2] Merel, S. E., & Paauw, D. S. (2017). Common Drug Side Effects and Drug-Drug Interactions in Elderly Adults in Primary Care. Journal of the American Geriatrics Society, 65(7), 1578–1585. https://doi.org/10.1111/jgs.14870  
‍^[3] Bhasin, S., Singh, A. B., Mac, R. P., Carter, B., Lee, M. I., & Cunningham, G. R. (2003). Managing the Risks of Prostate Disease During Testosterone Replacement Therapy in Older Men: Recommendations for a Standardized Monitoring Plan. Journal of Andrology, 24(3), 299–311. https://doi.org/10.1002/j.1939-4640.2003.tb02676.x  
‍^[4] Hackett, G. I. (2015). Testosterone Replacement Therapy and Mortality in Older Men. Drug Safety, 39(2), 117–130. https://doi.org/10.1007/s40264-015-0348-y  

KYZATREX is a controlled substance (CIII) because it contains testosterone. It is not known if KYZATREX is safe or effective in males younger than 18 years old. Improper use may affect bone growth in children. KYZATREX is not meant for use by women.
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In the phase 3 clinical trial for KYZATREX (n=155), 4 patients (2.6%) reported high blood pressure. A total of 5 patients (3.2%) began taking new antihypertensive medications after study start. No patient increased their dose of antihypertensive medication.
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Your healthcare provider will monitor your blood pressure while you are being treated with KYZATREX. If your blood pressure increases, you may need to start medication to control your blood pressure. If you are currently taking blood pressure medicines, they may need to be changed or new blood pressure medicines may need to be added. If your blood pressure cannot be controlled, KYZATREX may need to be stopped.
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See additional Important Safety Information, including boxed warning, for KYZATREX here.

KYZATREX (oral testosterone) can slightly raise blood pressure, especially in people on blood pressure medication, with little effect on heart rate^[1]. Intranasal testosterone gel (Natesto) has minimal impact on blood tests and low risk of increasing red blood cell count^[6]. Intramuscular testosterone cypionate raises red blood cell levels more significantly, which can be risky^[2][6]. Transdermal testosterone gel and long-acting intramuscular testosterone don't significantly increase heart problems^[3][5]. Overall, KYZATREX works well but needs blood pressure monitoring, especially for those with high blood pressure^[1][4][5]. 
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References: 
‍^[1] White, W. B., Bernstein, J. S., Rittmaster, R., & Dhingra, O. (2021). Effects of the oral testosterone undecanoate KYZATREX on ambulatory blood pressure in hypogonadal men. The Journal of Clinical Hypertension, 23(7), 1420–1430. https://doi.org/10.1111/jch.14297  
‍^[2] Rivero, M.-J., Ory, J., Diaz, P., Nannan Thirumavalavan, Han, S., Reis, I. M., & Ramasamy, R. (2023). Comparison of Hematocrit Change in Testosterone-deficient Men Treated with Intranasal Testosterone Gel vs Intramuscular Testosterone Cypionate: A Randomized Clinical Trial. The Journal of Urology, 210(1), 162–170. https://doi.org/10.1097/ju.0000000000003487  
‍^[3] A. Michael Lincoff, Bhasin, S., Panagiotis Flevaris, Mitchell, L. M., Shehzad Basaria, Boden, W. E., Cunningham, G. R., Granger, C. B., Khera, M., Thompson, I. M., Wang, Q., Wolski, K., Davey, D., Vidyasagar Kalahasti, Khan, N., Miller, M. G., Snabes, M. C., Chan, A., Dubcenco, E., & Li, X. (2023). Cardiovascular Safety of Testosterone-Replacement Therapy. https://doi.org/10.1056/nejmoa2215025  
‍^[4] Kovac, J. R., Rajanahally, S., Smith, R. P., Coward, R. M., Lamb, D. J., & Lipshultz, L. I. (2014). Patient Satisfaction with Testosterone Replacement Therapies: The Reasons Behind the Choices. The Journal of Sexual Medicine, 11(2), 553–562. https://doi.org/10.1111/jsm.12369  
‍^[5] Zitzmann, M., Cremers, J. F., Krallmann, C., & Kliesch, S. (2022). The HEAT-Registry (HEmatopoietic Affection by Testosterone): comparison of a transdermal gel vs long-acting intramuscular testosterone undecanoate in hypogonadal men. The Aging Male, 25(1), 134–144. https://doi.org/10.1080/13685538.2022.2063830  
‍^[6] Best, J., Gonzalez, D., Masterson, T., Blachman-Braun, R., Pai, R., & Ramasamy, R. (2020). A cross-sectional comparison of secondary polycythemia in testosterone-deficient men treated with nasal testosterone gel vs. intramuscular testosterone cypionate. Canadian Urological Association Journal, 15(2). https://doi.org/10.5489/cuaj.6651  

No. You may have heard about older forms of oral testosterone being liver toxic. The good news is that KYZATREX was specifically designed to be absorbed lymphatically. This means it bypasses your liver avoiding the liver toxicity associated with oral testosterone medications of the past. See Important Safety Information here.

Once approved to start treatment, your prescription is generated after the first consultation and sent to your address from one of our partnered pharmacies. The initial prescription includes a 30-day supply.

After the initial period, you'll receive communication about refilling your prescription. When necessary, you’ll get instructions on required additional lab work and when to schedule a follow up visit with your medical provider.

Your medication will be refilled after the initial 30-day supply. Subsequent refills are scheduled to ensure there is no interruption in your therapy. Refills are processed 27 days after your initial visit and each subsequent refill, aligning with your treatment plan.

After the initial prescription and two refills, you will need to be reassessed by your medical provider. This will align with your scheduled follow-up visits. During these visits, your medical provider will review your progress and lab results to determine if your prescription should be continued or adjusted. 

Once your refill is processed, the pharmacy will ship your medication directly to the address that you provide. You do not need to take any action to initiate the shipping process; however, ensuring your address details are current in our system will help avoid any delivery issues.

Manual refill requests are not necessary and are not encouraged, as they can disrupt the carefully planned treatment protocol. If you believe you are running low on your medication due to unforeseen circumstances, please contact our support team to discuss your situation. 

If you encounter any issues with your refill, such as not receiving it on time or receiving incorrect quantities, please contact our customer support immediately. Our team is here to ensure your treatment proceeds smoothly and will help resolve any issues promptly. 

To schedule routine lab work, visit LabCorp's website. Select "Routine Lab Work," then choose a lab. Finally, enter your zip code in the search bar to find a nearby location. 

You will need your personal details and contact information.

Yes, after selecting the lab location, you can choose an available date and time from the calendar. 

No, fasting is not required for the labwork you’ll need for TRT.

You’ll choose the “I have already paid or someone else is responsible” option, as your payment to us covers your labs.

After reviewing all the entered information, click "Create Appointment." You’ll receive a confirmation screen with your appointment details.

Initial lab tests are conducted at the start, followed by additional tests at 90, 180 days, and then every 180 days. 

Follow the instructions sent via email for scheduling lab work at designated LabCorp facilities. You must ensure all scheduled tests are completed as instructed. 

Labs include tests for T/Free T, CBC, SHBG, PSA, and Estradiol.

If you miss a dose of KYZATREX, take the missed dose as soon as possible if you remember shortly after. However, if it is nearly time for your next scheduled dose, skip the missed dose and do not take a double dose to make up for it. Continue with your regular dosing schedule after taking the missed dose or skipping it. If you are unsure about what to do after missing a dose, or if you miss multiple doses, contact your healthcare provider for specific advice. Always refer to the specific instructions provided by your healthcare provider or the medication's prescribing information.

Certain lifestyle changes can significantly impact testosterone levels, particularly in aging men. Weight management is crucial; studies show that weight loss is associated with increased testosterone and sex hormone-binding globulin (SHBG) levels, while weight gain leads to a decrease in these hormones. Obesity-induced hypogonadism can be mitigated by weight loss, as shown by a meta-analysis indicating significant increases in testosterone levels in obese men who lost weight^[1][3]. 
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Dietary changes also play a role; the effects of low-carbohydrate diets on testosterone levels are mixed, with short-term increases in cortisol levels possibly negatively impacting testosterone, while high-protein, low-carbohydrate diets have been shown to decrease resting testosterone levels. Additionally, diets low in fat combined with exercise can reduce serum hormones, including testosterone, but may also reduce prostate cancer cell growth^[2][7]. 
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Physically active male athletes show a chronic increase in testosterone with concurrent physiological increases in estradiol. 
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Regular exercise, especially resistance training and high-volume moderate-intensity exercise, has been shown to increase testosterone levels. A study found that higher volumes of exercise significantly increased testosterone and improved sexual function in obese men^[9]. Combining exercise with dietary interventions, such as a very-low-calorie diet, enhances the benefits on testosterone levels and overall health by maintaining lean body mass and improving glucose tolerance^[10]. Smoking cessation is also important, as quitting smoking is associated with a greater decline in testosterone levels compared to non-smokers, suggesting a direct impact of smoking on testosterone levels^[1]. Metabolic and bariatric surgeries, such as Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), significantly increase testosterone levels in men with obesity and improve inflammatory and endothelial biomarkers^[4][6][8]. Managing comorbid conditions like metabolic syndrome and type 2 diabetes is also critical, as lifestyle interventions, including diet and exercise, can improve glycemic control and metabolic health, increasing testosterone levels^[5]. Regular monitoring and consultation with healthcare providers are essential to tailor these interventions to individual needs. 
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References: 
‍^[1] Camacho, E. M., Huhtaniemi, I. T., O’Neill, T. W., Finn, J. D., Pye, S. R., Lee, D. M., Tajar, A., Bartfai, G., Boonen, S., Casanueva, F. F., Forti, G., Giwercman, A., Han, T. S., Kula, K., Keevil, B., Lean, M. E., Pendleton, N., Punab, M., Vanderschueren, D., & Wu, F. C. W. (2013). Age-associated changes in hypothalamic–pituitary–testicular function in middle-aged and older men are modified by weight change and lifestyle factors: longitudinal results from the European Male Ageing Study. European Journal of Endocrinology, 168(3), 445–455. https://doi.org/10.1530/eje-12-0890  
‍^[2] Whittaker, J., & Harris, M. (2022). Low-carbohydrate diets and men’s cortisol and testosterone: Systematic review and meta-analysis. Nutrition and Health, 026010602210830. https://doi.org/10.1177/02601060221083079 
‍^[3] Gie Ken‐Dror, Fluck, D., Christopher Henry Fry, & Thang Sieu Han. (2023). Meta‐analysis and construction of simple‐to‐use nomograms for approximating testosterone levels gained from weight loss in obese men. Andrology, 12(2), 297–315. https://doi.org/10.1111/andr.13484  
‍^[4] Cobeta, P., Pariente, R., Osorio, A., Marchan, M., Blázquez, L., Pestaña, D., Galindo, J., & Botella-Carretero, J. I. (2022). The Beneficial Changes on Inflammatory and Endothelial Biomarkers Induced by Metabolic Surgery Decreases the Carotid Intima-Media Thickness in Men. Biomolecules, 12(12), 1827–1827. https://doi.org/10.3390/biom12121827   
‍^[5] Heufelder, A. E., Saad, F., Bunck, M. C., & Gooren, L. (2009). Fifty-two-Week Treatment With Diet and Exercise Plus Transdermal Testosterone Reverses the Metabolic Syndrome and Improves Glycemic Control in Men With Newly Diagnosed Type 2 Diabetes and Subnormal Plasma Testosterone. Journal of Andrology, 30(6), 726–733. https://doi.org/10.2164/jandrol.108.007005  
‍^[6] Ann-Cathrin Koschker, & Seyfried, F. (2023). Comment on: The male patient with obesity undergoing metabolic and bariatric surgery: changes in testosterone levels correlate with weight loss after one-anastomosis gastric bypass and Roux-en-Y gastric bypass. Surgery for Obesity and Related Diseases, 19(7), 705–706. https://doi.org/10.1016/j.soard.2023.01.009
^[7] Tymchuk, C. N., Barnard, R. J., Ngo, T. H., & Aronson, W. J. (2002). Role of Testosterone, Estradiol, and Insulin in Diet- and Exercise-Induced Reductions in Serum-Stimulated Prostate Cancer Cell Growth In Vitro. Nutrition and Cancer, 42(1), 112–116. https://doi.org/10.1207/s15327914nc421_15  
‍^[8] Jedamzik, J., Bichler, C., Daniel Moritz Felsenreich, Brugger, J., Jakob Eichelter, Nixdorf, L., Krebs, M., Itariu, B., Langer, F. B., & Prager, G. (2023). The male patient with obesity undergoing metabolic and bariatric surgery: changes in testosterone levels correlate with weight loss after one-anastomosis gastric bypass and Roux-en-Y gastric bypass. Surgery for Obesity and Related Diseases, 19(7), 699–705. https://doi.org/10.1016/j.soard.2022.12.034  
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‍^[10] Krotkiewski, M., Toss, L., Björntorp, P., & Holm, G. (1981). The effect of a very-low-calorie diet with and without chronic exercise on thyroid and sex hormones, plasma proteins, oxygen uptake, insulin and c peptide concentrations in obese women. International Journal of Obesity, 5(3), 287–293. https://pubmed.ncbi.nlm.nih.gov/7024157/

Stopping KYZATREX testosterone therapy should not be done abruptly or without medical supervision, even if you feel better. Consult your healthcare provider before making any changes, as sudden discontinuation can lead to the return of symptoms like fatigue, decreased libido, mood swings, and reduced muscle mass, as well as hormonal imbalances. If discontinuation is necessary, a gradual reduction in dosage under medical supervision is recommended. Regular follow-up appointments and monitoring are essential to manage discontinuation safely. Additionally, incorporating lifestyle changes such as weight management, regular exercise, a balanced diet, and stress reduction can help maintain health after stopping therapy. Always seek medical advice before altering your therapy regimen.

Please report any side effects to your medical provider immediately. They may adjust your treatment or take additional measures to manage side effects.

The initial cost for the KYZATREX program is $129. If approved for the program based on the medical provider's analysis of your blood results, the cost of medication is included in your first month of treatment. After the first month, there is a recurring cost of $229, which includes the cost of medication and any additional required lab tests (walk-ins) and provider visits.

The initial payment will be authorized after checkout following your initial treatment protocol questionnaire.

Once you've made a payment, the outcome will be communicated to you on-screen and via email. Our platform uses Recurly for processing payments, and notifications are sent for successful transactions. Billing emails will include a copy of your invoice in PDF format. For failed transactions, the failure reason will be presented to you on-screen.

When it’s time for your refill, we’ll email you a link to complete payment for your next month of medication. Over the course of your treatment plan, you may also be asked to answer a short questionnaire to see how your treatment is going.

KYZATREX is a cash-pay medication, removing the complications of insurance. Your doctor will provide you with instructions on how to fill your KYZATREX prescription.
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Experience the difference twice-daily KYZATREX can make in managing Low T.

‍In the event of a payment failure, you'll be notified via email for your next steps. Additionally, our support team will be informed and will reach out to you to assist in resolving the issue to prevent disruption in your treatment plan.